Propofol reduces succinylcholine induced increase of masseter muscle tone

Chemical skinning artifact appears to increase sensitivity of masseter muscle to halothane and succinylcholine.

In Reply:-We thank Dr. Rampil for bringing up the matter of experiment design. Although in some circumstances system identification using a single fixed-size step change input may indeed suffer from the limitations described, our approach is very close to optimal. In our study,' we applied one or more steps in and out of end-tidal anesthetic concentration of variable duration depending on the o...

Masseter muscle rigidity, elevated creatine kinase, and rhabdomyolysis following succinylcholine administration: a case report.

This case report details the onset of masseter muscle rigidity, elevated creatine kinase levels, and rhabdomyolysis following a sevoflurane mask induction and succinylcholine administration in a 12-year-old boy. The patient had no family or personal history of neuromuscular disease or malignant hyperthermia. Hyperkalemia, metabolic acidosis, and rhabdomyolysis occurred within 75 minutes of mass...

Succinylcholine-triggerred "masseter spasm" may be a variant normal response.

Endogenous -Aminobutyric Acid Modulates Tonic Guinea Pig Airway Tone and Propofol-induced Airway Smooth Muscle Relaxation

Background: Emerging evidence indicates that an endogenous autocrine/paracrine system involving -aminobutyric acid (GABA) is present in airways. GABAA channels, GABAB receptors, and the enzyme that synthesizes GABA have been identified in airway epithelium and smooth muscle. However, the endogenous ligand itself, GABA, has not been measured in airway tissues. The authors sought to demonstrate t...

Effect of fazadinium (Fazadon) on muscle fasciculations induced by succinylcholine.

The effects on muscle fasciculations and ease of tracheal intubation of pretreatment with fazadinium before administration of succinylcholine were evaluated in 85 patients. Four dose levels of fazadinium evaluated were 0.05 mg . kg-1, 0.075 mg . kg-1, 0.10 mg . kg-1 and 0.15 mg . kg-1. The 0.05 mg . kg-1 dose did not always prevent succinylcholine-induced muscle fasciculations. The 0.15 mg . kg...